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Last Updated 04/17/18
 

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The leading cause of death for end-stage renal disease patients is cardiovascular disease (CVD).  According to the United States Renal Data System (USRDS) one uniform finding is the progressively increased representation for each cardiovascular
condition with respect to advanced CKD stage and age. In the non-CKD population, for example, only 3.6 percent of patients age 66–69 have congestive heart failure (CHF), compared to 15 percent of those age 85 and older. Among patients with Stage 4–5 CKD, these numbers reach 34 and 48 percent. CHF is a common comorbid condition in elderly patients, particularly among those with advanced CKD. 2012

The high risk of CVD in end-stage renal disease is partly due to the fact that the dialysis patient population has a higher prevalence of conditions that are known risk factors for CVD in the general population, such as older age, hypertension (high blood pressure), high cholesterol levels, diabetes, and physical inactivity. The high risk may also be partly caused by factors involved in renal failure, including proteinuria (protein in urine), fluid retention, irregular blood chemistries, anemia, blood clotting disorders, and chronic inflammation.

The two most common CVD conditions seen in patients with end-stage renal disease are coronary artery disease (CAD) and left ventricular hypertrophy (LVH).  The physical symptoms of these two conditions may often be the same, and include chest pain, heart attack, congestive heart failure, and arrhythmias.

Warning:  Changes should never be made in a patient's treatment or care based solely on the information found here.  Every patient has unique healthcare concerns and considerations and all these factors must all be taken into account before any changes can be safely made.  All medical and therapeutic decisions must come from a qualified health care provider.  Read RenalWEB's Legal Disclaimer before proceeding.


  NEWS & LATEST ARTICLES
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New Insights into the Key Role of Interleukin 6 in Vascular Calcification of Chronic Kidney Disease - Free, Full-Text Article from NDT. - April 2018

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SNF472, A Novel Inhibitor of Vascular Calcification, Could Be Administered during Hemodialysis to Attain Potentially Therapeutic Phytate Levels - Free, Open Access Article from Journal of Nephrology. - April 2018

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Free, Open Access Articles from Kidney International - April 2018

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New Blood Pressure Guidelines Could Put Lives at Risk, Say Experts - Press release from University of Sydney. - April 16, 2018

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Association of a Smartphone Application With Medication Adherence and Blood Pressure Control—The MedISAFE-BP Randomized Clinical Trial - Free, full-text, New Online article, commentary, and related research letter extract from JAMA Internal Medicine. - April 16, 2018

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Music Intensifies Effects of Anti-Hypertensive Medication - April 16, 2018

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Hemodynamic Response to Fluid Removal during Hemodialysis: Categorization of Causes of Intradialytic Hypotension - Advance Article abstract from NDT. - April 14, 2018

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Zinc Inhibits Phosphate-Induced Vascular Calcification through TNFAIP3-Mediated Suppression of NF-?B - JASN Express abstract. - April 13, 2018

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Do Plasma Neprilysin Activity and Plasma Neprilysin Concentration Predict Cardiac Events in Chronic Kidney Disease Patients? - Advance Article Abstract from NDT. - April 9, 2018

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Study Found People Would Rather Pop a Pill or Sip Tea Than Exercise to Treat High Blood Pressure - Press release from the American Heart Association. - April 7, 2018

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Hemodialysis-Induced Cardiovascular Disease - Early View abstract from Seminars in Dialysis. - April 6, 2018

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Chronic Illnesses, Functional Limitations a Risk in Older Adults with Heart Failure - Press release from the American Geriatrics Society. - April 5, 2018

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Articles from Medscape Nephrology (registration required, but free)  - April 5, 2018

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Preeclampsia as a Form of Type 5 Cardiorenal Syndrome: An Underrecognized Entity in Women's Cardiovascular Health - Free, full-text, Issue-in-Progress article from CardioRenal Medicine. - April 4, 2018

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Relaxation Response May Reduce Blood Pressure by Altering Expression of a Set of Genes - Press release from Beth Israel Deaconess Medical Center. - April 4, 2018

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$18 Million Gift Creates Nation's First Center for Heart Failure and Arrhythmia - Press release from Ohio State University Wexner Medical Center. - April 3, 2018

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Aortic Stenosis Is a Risk Factor for All-Cause Mortality in Patients on Dialysis: a Multicenter Prospective Cohort Analysis - Free, Open Access Article from BMC Nephrology. - April 3, 2018

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Cardiovascular Disease and Risk Management: Review of the American Diabetes Association Standards of Medical Care in Diabetes 2018 - Free, full-text, Latest clinical guidelines from Annals of Internal Medicine. - April 3, 2018

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Evidence-based Recommendations for Beta Blockers Use in ESRD Patients - Article from the European Nephrology Portal. - April 2, 2018

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A Prospective Randomized Study of Stent Graft Placement after Balloon Angioplasty Versus Balloon Angioplasty Alone for the Treatment of Hemodialysis Patients with Prosthetic Graft Outflow Stenosis - Article in Press abstract from Journal of Vascular Surgery. - April 2, 2018

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Ablation Bests Medical Therapy for AFib With Heart Failure - Article from Renal & Urology News. - April 2, 2018

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Effect of Lanthanum Carbonate on All-Cause Mortality in Patients Receiving Maintenance Hemodialysis: a Meta-Analysis of Randomized Controlled Trials - Free, full-text, Issue-in-Progress article from Kidney & Blood Pressure Research. - March 29, 2018

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The Ebb and Flow of Echocardiographic Cardiac Function Parameters in Relationship to Hemodialysis Treatment in Patients with ESRD - JASN Express abstract. - March 28, 2018

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Management of High Blood Pressure in Children: Similarities and Differences between US and European Guidelines - First Online abstract from Pediatric Nephrology. - March 28, 2018

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Add-On Antihypertensive Medications to Angiotensin-Aldosterone System Blockers in Diabetes — A Comparative Effectiveness Study - CJASN Express abstract. - March 23, 2018

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Women's Antibiotic Use Linked to Higher Risk of Death from Heart Disease, Other Causes - Press release from the American Heart Association. - March 22, 2018

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Depression Could Be a Risk Factor for A-Fib: Study - Article from HealthDay. - March 22, 2018

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Sugary Sodas Linked Again to Increased Heart Risks - Article from HealthDay. - March 21, 2018

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Grilling and Other High-Temperature Cooking May Raise Risk of High Blood Pressure - Press release from the American Heart Association. - March 21, 2018

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Blood Pressure Lowering Treatment Strategies Based on Cardiovascular Risk Versus Blood Pressure: a Meta-Analysis of Individual Participant Data - Free, full-text article from PLOS Medicine. - March 20, 2018

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Coffee Consumption and Incident Kidney Disease: Results From the Atherosclerosis Risk in Communities (ARIC) Study - Article in Press abstract from American Journal of Kidney Diseases. - March 20, 2018

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Majority of U.S. Adults Have Poor Heart Health: Study - Article from HealthDay. - March 19, 2018

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Utility of Implantable Cardioverter Defibrillators in Chronic Kidney Disease - Article in Press abstract from Kidney International. - March 17, 2018

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Slightly Elevated Blood Sugar Tied to Heart and Kidney Problems - Article from Reuters. Online First abstract from The Lancet Diabetes & Endocrinology. - March 16, 2018

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Can You Be Obese But Heart-Healthy? Study Says No - Article from HealthDay. - March 16, 2018

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Individualizing Blood Pressure Targets for People With Diabetes and Hypertension — Comparing the ADA and the ACC/AHA Recommendations - Free, full-text, New Online viewpoint article from the Journal of the American Medical Association. - March 15, 2018

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Press Releases from Intermountain Healthcare - March 12, 2018

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Low-Dose 'Triple Pill' Lowers Blood Pressure More Than Usual Care - Press release from American College of Cardiology. - March 12, 2018

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Another Fallout from the Great Recession: Fewer People Took Their Blood Pressure and Diabetes Medications - Article from STAT. - March 12, 2018

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Barbershop-based Healthcare Study Successfully Lowers High Blood Pressure in African-American Men - Press release from Cedars-Sinai Medical Center. Free, full-text, Recently Published article from The New England Journal of Medicine. - March 12, 2018

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Assessment and Management of Fluid Overload in Children on Dialysis - Free, full-text, First Online article from Pediatric Nephrology. - March 9, 2018

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The Effect of Pregnancy on the Long-Term Risk of Graft Loss, Cardiovascular Disease and Death in Kidney Transplanted Women in Norway: a Retrospective Cohort Study - Online First abstract from Transplantation. - March 9, 2018

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Spironolactone Favored Over Clonidine for Resistant Hypertension - (Registration required, but free.) Article from Medscape Nephrology. - March 9, 2018

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New Blood Pressure App and Hardware Rivals Arm Cuff Accuracy - Press release from Michigan State University. - March 9, 2018

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Free, Full-Text, Issue-In-Progress Articles from Kidney and Blood Pressure Research - February 16 - March 6, 2018

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Osteocardiology: Defining the Go/No-Go Time Point for Therapy - Free, full-text, editorial from Cardiology. - January 27, 2018

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Stroke Risk and Outcomes in Patients with Chronic Kidney Disease or End-Stage Renal Disease: Two Nationwide Studies - Free, Open Access Article from PLOS ONE. - January 12, 2018

blue ball News Releases from the American Heart Association  Continually Updated!
blue ball Latest Cardiovascular Disease News Stories - Yahoo! News Continually Updated!
blue ball Latest Hypertension News Stories - Yahoo! News Continually Updated!
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  WEB RESOURCES
blue ball Latest Scientific Journal Articles on Cardiovascular Disease
Acute and Chronic Management of Atrial Fibrillation in Patients With Late-Stage CKD - Full-text article from the American Journal of Kidney Diseases. - April 2009
Cardiovascular disease calculator and related abstract from BMJ - July 2001
Cardiovascular complications of pediatric chronic kidney disease - educational feature from Pediatric Nephrology - February 2008
Diseases & Conditions from the American Heart Association web site
Evaluation of cardiac function in the dialysis patient—a primer for the non-expert - editorial from Nephrology Dialysis Transplantation - June 2006
The Guide to Medicare Preventive Services (pdf) from the Medlearn/Centers for Medicare & Medicaid Services web site
Division for Heart Disease and Stroke Prevention: Interactive Atlas from the Centers for Disease Control and Prevention (CDC) web site
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Free, Full-Text, New Online Articles from the Journal of the American Medical Association - November 20, 2017

High Blood Pressure and Kidney Disease: How Are They Connected? from the Kidney & Urology Foundation of America (KUFA) web site
blue ball Hypertension - this is a growing library of key high-impact articles in nephrology, chosen by UKidney's contributors as suggested reading for nephrology trainees and practitioners.
National Cholesterol Education Program (NCEP) (pdf) from the NIH web site. Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults.
Smoothie Recipe Book for Renal and Heart Health by Victoria L Hulett JD (Author), Jennifer L Waybright RN (Contributor)
Understanding Cardiac Biomarkers in ESRD: Frequently Asked Questions and the Promise of Clinical Application - free, full-text review (43-page pdf) from Nephrology. - October 15, 2010
American Heart Association web site
American College of Cardiology web site
American Society of Hypertension web site
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Cardio Renal Society of America - web site Twitter #CardioRenal

HeartPoint - multimedia site for patient information and education
National Heart, Lung and Blood Institute web site
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  ESSENTIALS AND CLASSICS
Heart Failure Treatment from WebMD
High Blood Pressure and Kidney Disease from the NIDDK web site (in layman's terms)
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure - 2003
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  PUBMED SEARCHES (National Library of Medicine's MEDLINE Database)
MEDLINE PLUS for Heart Diseases Continually Updated!
heart AND dialysis Continually Updated!
hypertension AND dialysis Continually Updated!
cardiovascular disease AND end-stage renal disease AND dialysis Continually Updated!
MEDLINE / Pubmed Information from the National Library of Medicine
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  CLINICAL GUIDELINES
AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update
2003 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension
blue ball Clinical Practice Guidelines for cardiovascular disease (search result) from the  National Guideline Clearinghouse web site
blue ball Management of Heart Failure in Advancing CKD: Core Curriculum 2018 from the American Journal of Kidney Diseases
Treatment of Anemia in Patients With Heart Disease: A Clinical Practice Guideline From the American College of Physicians article from the Annals of Internal Medicine - December 2013
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  K/DOQI™ -  Kidney Disease Outcomes Quality Initiative
Clinical Practice Guidelines For Chronic Kidney Disease: Table of Contents
Clinical Practice Guidelines for Cardiovascular Disease in Dialysis Patients
Clinical Practice Guidelines for Hypertension and Antihypertensive Agents in Chronic Kidney Disease
Clinical Practice Guidelines for Managing Dyslipidemias in Chronic Kidney Disease


KDIGO™ -  Kidney Disease Improving Global Outcomes ( pronounced "kay de go" )

Kidney Disease Improving Global Outcomes (KDIGO) web site


  DISCUSSION FORUM
General Dialysis Nursing Issues and Questions (No dedicated RenalWEB forum)
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  WEB SEARCH ENGINES
Cardiovascular Disease web sites by Yahoo! Continually Updated!
Cardiovascular Disease web sites by AOL Continually Updated!
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  INPUT / SUGGESTIONS
E-mail to RenalWEB on the Cardiovascular Disease Topic
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