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Last Updated 09/10/17
 

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Unless closely monitored, renal bone disease (renal osteodystrophy) is a problem that will be experienced by most people suffering from end stage renal disease (ESRD). Renal bone disease is a complex issue and involves many more factors than can be listed in this limited space. Only the very basics are outlined here.

First, the kidneys are involved in the synthesis of vitamin D, which is the most essential factor regulating intestinal absorption of calcium in humans. When the kidneys fail and less vitamin D is created, the amount of calcium absorbed by the intestines is reduced. Calcium is most essential substance for bone maintenance and health. Next, calcium and phosphorus levels in the blood (which are normally regulated by the kidneys) are dependent upon each other. Therefore, when the kidneys fail and the phosphorus level in the blood goes up, the (free) calcium level in the blood decreases. In response to these two factors that lower serum calcium, the body then increases the parathyroid hormone (PTH) level in the blood.  PTH causes calcium to be released from the bones in order to increase the serum calcium level.  Left untreated, an ESRD patient will have bones that are depleted of calcium, brittle, and likely to fracture.

Treatment and prevention of renal bone disease usually include the use of phosphate binders and vitamin D analogs (to reduce PTH levels).  In the past, treatment frequently included the removal of the parathyroid glands.

Normal serum calcium is 8.5-10.8 mg/dL.

Normal serum phosphorus for dialysis patients is 3.5 to 5.5 mg/dl High phosphorus levels also cause itchy skin.

It is recommended that ESRD patients maintain a calcium phosphorous product that is below 70.

Warning:  Changes should never be made in a patient's treatment or care based solely on the information found here.  Every patient has unique healthcare concerns and considerations and all these factors must all be taken into account before any changes can be safely made.  All medical and therapeutic decisions must come from a qualified health care provider.  Read RenalWEB's Legal Disclaimer before proceeding.


  NEWS AND LATEST INFORMATION
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Long-Term Assessment of the Safety and Efficacy of PA21 (Sucroferric Oxyhydroxide) in Japanese Hemodialysis Patients With Hyperphosphatemia: An Open-Label, Multicenter, Phase III Study - Free, Full-Text Article from Journal Of Renal Nutrition. - September 2017

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Bone Turnover Markers Are Associated with Bone Density, but Not with Fracture in End Stage Kidney Disease: a Cross-Sectional Study - Free, Open Access Article from BMC Nephrology. - September 6, 2017

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Clinical Trial Aims to Slow Bone Loss in Dialysis Patients - News release from the University of Kentucky. - September 5, 2017

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Progression of Arterial Stiffness Is Associated with Changes in Bone Mineral Markers in Advanced CKD - Free, Open Access Article from BMC Nephrology. - September 4, 2017

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Total Parathyroidectomy Versus Total Parathyroidectomy with Autotransplantation for Secondary Hyperparathyroidism: Systematic Review and Meta-Analysis - Free, Open Access article from Renal Failure. - August 30, 2017

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The Cost of Phosphate Binders - Tweet from Graham Abra, MD. - August 28, 2017

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Clinical Value of Ambulatory Blood Pressure in Pediatric Patients after Renal Transplantation - Free, Open Access, First Online educational review from Pediatric Nephrology. - August 25, 2017

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The Role of Parathyroidectomy in the Management of Secondary Hyperparathyroidism. - Published Ahead-of-Print Abstract from Current Opinion in Nephrology and Hypertension. - August 24, 2017

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Long-Term Effects of Etelcalcetide As Intravenous Calcimimetic Therapy in Hemodialysis Patients with Secondary Hyperparathyroidism - First Online abstract from Clinical and Experimental Nephrology. - August 23, 2017

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Update on the Role of Bone Biopsy in the Management of Patients with CKD-MBD - First Online abstract from Journal of Nephrology. - August 22, 2017

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Researchers: Iron-based Binders Best for Hyperphosphatemia - Article from Renal & Urology News. - August 21, 2017

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The Often Missed Diagnosis of Primary Hyperparathyroidism - (Registration required, but free.) Article and video from Medscape Nephrology. - August 18, 2017

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Clinical Course after Parathyroidectomy in Adults with End-Stage Renal Disease on Maintenance Dialysis - Free, full-text, Advance Article from Clinical Kidney Journal. - August 17, 2017

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Impact of Nutritional Index on the Association between Phosphorus Concentrations and Mortality in Hemodialysis Patients: a Cohort Study from Dialysis Outcomes and Practice Pattern Study in Japan - Free, full-text article from BMJ Open. - August 1, 2017

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Tweet from Daniel Coyne on KDIGO and Sensipar - @DrDanMO. - July 25, 2017

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  WEB RESOURCES
blue ball Latest Scientific Journal Articles on Bone Disease Continually Updated!
Bone Density Studies Benefits Brochure (pdf format requires Adobe Acrobat reader)  from the Centers for Medicare & Medicaid Services (CMS)
National Institutes of Health Osteoporosis and Related Bone Diseases - National Resource Center web site
Bone Disease from the Kidney Patient Guide web site of the UK
blue ball Bone and Mineral Metabolism - this is a growing library of key high-impact articles in nephrology, chosen by UKidney's contributors as suggested reading for nephrology trainees and practitioners.
AAKP Nutrition Coundter: A Reference for the Kidney Patient from the American Association of Kidney Patients web site
Chronic Kidney Disease Mineral and Bone Disorder in Children - full-text educational feature from Pediatric Nephrology
Mineral and Bone Disorder in CKD Stage 3 and 4 from the National Kidney Foundation web site
Renassist is a value-added program provided to patients to assist them in determining how they can access Renagel through their current health insurance from the Genzyme web site
Drug and Supplements Info: Calcium Carbonate from NLM MedLine Plus 
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  ESSENTIALS AND CLASSICS
Bone Mineral Metabolism Fact Sheet (pdf format requires Adobe Acrobat reader.) from the American Nephrology Nurses’ Association
Chronic Kidney Disease-Mineral and Bone Disorder - from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) web site
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Washington University Nephrology Web Episode - Bone Mineral Metabolism - Video from the Renal Fellow Network blog. 

Renal Osteodystrophy Topic from MedicineNet.com
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  PUBMED SEARCHES (National Library of Medicine's MEDLINE Database)
osteodystrophy AND dialysis   Continually Updated!
bone disease AND dialysis   Continually Updated!
phosphate binder   Continually Updated!
hyperparathyroidism AND dialysis    Continually Updated!
secondary hyperparathyroidism   Continually Updated!
MEDLINE / Pubmed Information from the National Library of Medicine
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  K/DOQI™ -  Kidney Disease Outcomes Quality Initiative
Clinical Practice Guidelines For Chronic Kidney Disease
 

  Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease
 

  Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease in Children
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  KDIGO™ -  Kidney Disease: Improving Global Outcomes
Clinical Practice Guidelines: Table of Contents
 

  Clinical Practice Guideline for CKD-Mineral and Bone Disorder (CKD-MBD) (Published 2017)

  WEB SEARCH ENGINES
Renal Osteodystrophy-related web pages by Yahoo! Continually Updated!
Renal Osteoporosis-related web pages by Yahoo! Continually Updated!
Renal Osteoarthritis-related web pages by Yahoo! Continually Updated!
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  DISCUSSION FORUM
General Dialysis Nursing Issues and Questions (No dedicated RenalWEB forum yet for this topic)
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  PRODUCTS
PHOSLYRA (calcium acetate oral solution) solution by Fresenius Medical Care North America
RenVela® Tablets (sevelamer) - phosphate binder
Hectorol™ Capsules (vitamin D analog for treating secondary hyperparathyroidism)
Rocaltrol ® brand of (calcitrol) Capsules and Oral Solution (vitamin D analog) - Product Information
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  RELATED TOPICS
Well Nourished Patient topic page from RenalWEB
aluminum and dialysis (PUBMED Search) Continually Updated!
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  INPUT / SUGGESTIONS
E-mail to RenalWEB on the Bone Disease Management Topic
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