RenalWEB Home Page
Last Updated 4/21/19

Chronic kidney disease (CKD) is permanent kidney damage due to injury or disease. More than 20 million Americans-one in nine adults-have chronic kidney disease, and most don't even know it. More than 20 million others are at increased risk.

How long you can live with CKD depends on your age, other health problems, and how involved you become in your care. Some people with early CKD never experience kidney failure. Others reach kidney failure (end-stage renal disease (ESRD)) and live for decades with dialysis or kidney transplants.

Simple tests in a doctor's office can detect chronic kidney disease in its early stages when lifestyle changes and medication can be prescribed to delay or prevent the progression of kidney disease and its complications. Left untreated, chronic kidney disease may ultimately lead to kidney failure and/or heart disease.

There are many risk factors that make having CKD more likely, with the leading risk factors being diabetes, hypertension, and a family history of CKD.

Warning: Changes should never be made in a patient's treatment or care based solely on the information found here.  All patients have unique healthcare concerns and considerations and these must all be taken into account before any changes can be safely made.  All medical and therapeutic decisions must come from a qualified health care provider.  Read RenalWEB's Legal Disclaimer before proceeding.

  NEWS and LATEST ARTICLES

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Free, Full-Text Articles from Current Opinion in Nephrology and Hypertension - May 2019

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Published Ahead of Print CJASN Articles - April 2019

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Clinical and Economic Disparities between CKD and ESKD Care - Article from Healio (registration required.) - April 2019

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Abstracts of Comment & Response from JAMA Internal Medicine - April 2019

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Increasing Access to Integrated ESKD Care As Part of Universal Health Coverage - Free, Open Access article from supplemental issue of Kidney International. News brief from the International Society of Nephrology. - April 2019

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The US Renal Data System at 30 Years: A Historical Perspective - Free, Full-Text Article from American Journal of Kidney Diseases. - April 2019

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NAV-KIDS2 Trial: Protocol for a Multi-Center, Staggered Randomized Controlled Trial of a Patient Navigator Intervention in Children with Chronic Kidney Disease - Free, Open Access article from BMC Nephrology. - April 18, 2019

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Soon, Kidneys-on-a-Chip Will Rocket to Space Station - Press release from the University of Washington School of Medicine. - April 17, 2019

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NKF Study Reveals Challenges in Co-Management of Kidney Patients in Primary Care - Press release from the National Kidney Foundation. - April 17, 2019

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Is CREDENCE a Game Changer for Diabetic Nephropathy? - (Registration required, but free.) Article from Medscape Nephrology. - April 17, 2019

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Kidney Disease Awareness and Knowledge among Survivors of Acute Kidney Injury - Online First abstract from American Journal of Nephrology. - April 17, 2019

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Hypoglycemia in People with Type 2 Diabetes and CKD - Published Ahead of Print CJASN article. - April 17, 2019

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In the NEWS: Credence, Rise of the Nephron Throne - Posting from the NephronPower blog. - April 16, 2019

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Association between Prediabetes (defined by HbA1C, fasting plasma glucose, and impaired glucose tolerance) and the Development of Chronic Kidney Disease: a 9-Year Prospective Cohort Study - Free, Open Access article from BMC Nephrology. - April 16, 2019

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Scientists Report New Approach to Reduce or Prevent Renal Fibrosis - Press release from the American Journal of Pathology. - April 16, 2019

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Better Manage Diabetes with Technology - Article from Medical Economics. - April 16, 2019

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Breakthrough Kidney Disease Treatment Offers Hope for Hundreds of Millions with Diabetes Worldwide - Press releases from the University of Oxford and Stanford University. Article from HealthDay. - April 15, 2019

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Articles from Medscape Nephrology (registration required, but free) - April 15, 2019

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Late Breaking Clinical Trials from ISN World Congress of Nephrology
See (live-) streaming feeds.  - April 15, 2019

  • CREDENCE (BLOCKBUSTER!): Free, full-text NEJM article and editorial extractResults from the George Institute. NKF statement. Press release from Janssen Pharmaceutical. YouTube video of presentation. Twitter #CREDENCETRIAL, Tweets  #1,  #2.

    "Data from the CREDENCE trial published today in the New England Journal of Medicine demonstrate that INVOKANA® (Canagliflozin) can help reduce the risk of end stage renal disease (ESRD) and cardiovascular events in patients already diagnosed with Type 2 diabetes and chronic kidney disease (CKD). If this supplemental indication is approved by the Food and Drug Administration (FDA), it would be the first new treatment for diabetic kidney disease (DKD) in decades."
  • ACTIVE: Tweet: #1
  • SONAR:
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Atrasentan and Renal Events in Patients with Type 2 Diabetes and Chronic Kidney Disease (SONAR): a Double-Blind, Randomized, Placebo-Controlled Trial - Online First abstract from The Lancet. - April 14, 2019

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HIV Antiretroviral Therapy: Also Anti-Kidney? - Posting from the Renal Fellow Network blog. - April 14, 2019

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Evaluating a New International Risk-Prediction Tool in IgA Nephropathy - New Online abstract from JAMA Internal Medicine. - April 13, 2019

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Secular Trends in End-Stage Kidney Disease Requiring Renal Replacement Therapy in Japan: Japanese Society of Dialysis Therapy Registry Data from 1983 to 2016 - Accepted Articles Abstract from Nephrology. - April 13, 2019

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New: Toolkit on Care Transitions - (103-page pdf) Best practices identified by the ESRD Forum of Networks Medical Advisory Council (MAC). - April 12, 2019

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Children of a Lesser God: Exclusion of Chronic Kidney Disease Patients from Clinical Trials - Free, full-text, Advance Article from NDT. - April 12, 2019

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Kidney Health Atlas Reveals Global Burden of Disease and Inequities in Access - Press release from the International Society of Nephrology (ISN) . Article from Bloomberg. - April 11, 2019

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Case 11-2019: A 49-Year-Old Man with HIV Infection and Chronic Kidney Disease - (Registration required, but free.) Case report from the New England Journal of Medicine. - April 11, 2019

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Analysis of 2897 Hospitalization Events for Patients with Chronic Kidney Disease: Results from CKD-JAC Study - Free, Open Access, First Online article from Clinical and Experimental Nephrology. - April 9, 2019

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Kidney Disease/Failure Warning on Deodorant - Posting from the Dialysis Discussion Uncensored Facebook page. - April 8, 2019

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Most Exposed: the Endothelium in Chronic Kidney Disease - Advance Article abstract from NDT. - April 8, 2019

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Too Much of a Good Thing? High Doses of Vitamin D Can Lead to Kidney Failure - Press release from the Canadian Medical Association Journal. - April 8, 2019

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Incidence and Prognosis of Acute Kidney Diseases and Disorders Using an Integrated Approach to Laboratory Measurements in a Universal Health Care System - Free, full-text article from JAMA Network Open. - April 5, 2019

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Burden of CKD in the United States: What Have We Learned? - Article from Medscape Nephrology (registration required, but free). - April 5, 2019

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Social Exclusion, Intravenous Drug Use and the Kidneys - Posting from the Renal Fellow Network blog. - April 5, 2019

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When to Initiate Dialysis in Children and Adolescents: Is Waiting Worthwhile? - Free, full-text, Article in Press from American Journal of Kidney Diseases. - April 4, 2019

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The Cost of Care for People With Chronic Kidney Disease - Free, Open Access article from Canadian Journal of Kidney Health and Disease. - April 4, 2019

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Acute Dialysis in Children: Results of a European Survey - First Online abstract from Journal of Nephrology. - April 4, 2019

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Free, Open Access, Articles in Press from Kidney International Reports - April 3, 2019

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Wearables for Hyperkalemia Screening: Hold the Applause? - (Registration required, but free.) Article from MedPage Today. - April 3, 2019

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Mortality of Critically ill Children Requiring Continuous Renal Replacement Therapy — Effect of Fluid Overload, Underlying Disease, and Timing of Initiation - Abstract from Pediatric Critical Care Medicine. - April 1, 2019

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Management of Small Kidney Tumors in 2019 - New Online abstract from the Journal of the American Medical Association. - April 1, 2019

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Diabetes Standards of Care Updated to Include New Data on CV, Kidney Health - Posting from NEJM Journal Watch. Press release from the American Diabetes Association. - April 1, 2019

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Published Ahead of Print CJASN Articles - March 2019

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Got CKD? There's an App for That - Do Smartphone Apps Help Kidney Disease Patients Manage Their Disease? - Press release and free, full-text, Published Ahead of Print CJASN article the American Society of Nephrology. - March 2019

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You Are Just Now Telling Us About This? African American Perspectives of Testing for Genetic Susceptibility to Kidney Disease - Free, full-text, Published Ahead of Print JASN perspective piece. - March 2019

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New Renal, CV Disease Indication Sought for Canagliflozin - (Registration required, but free.) Article from Internal Medicine News. - March 30, 2019

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Chronic Kidney Disease of Undetermined Causes, Described Originally in Central America and Sri Lanka - Press release from Barcelona Institute for Global Health. - March 29, 2019

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Free, Open Access Articles from BMC Nephrology - March 28-29, 2019

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Recent Advances in Acute Kidney Injury and Its Consequences and Impact on Chronic Kidney Disease - Published Ahead of Print abstract from Current Opinion in Nephrology and Hypertension. - March 28, 2019

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Iodine Excess in Children with Kidney Disease: Are We Missing Hypothyroidism? - Free, full-text, First Online editorial commentary from Pediatric Nephrology. - March 26, 2019

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Statin Use and the Risk of Acute Kidney Injury in Older Adults - Free, Open Access Article from BMC Nephrology. - March 25, 2019

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Peptide Shows Promise for Protecting Kidneys from Nephritis - Press release from Medical College of Georgia at Augusta University. - March 25, 2019

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An Intern's Guide to AKI Work-up - Posting from The Kidney Zone blog. - March 24, 2019

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Mayo Clinic Minute: When Your Kidneys Fail - Video and article. - March 22, 2019

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Predicting Risk of Recurrent Acute Kidney Injury: A Systematic Review - Free, Full-Text, Online First article from Nephron. - March 21, 2019

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Pre-Dialysis Care and Cardiovascular Outcomes: Why the Lead Up to Dialysis Matters - Free, Full-Text, Articles in Press from Kidney International Reports. - March 20, 2019

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Decision Making for the Initiation and Termination of Dialysis in Patients with Advanced Cancer - Early View abstract from Seminars in Dialysis. - March 20, 2019

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Spectrum of Acute Kidney Injury Associated with Cocaine Use: Report of Three Cases - Free, Open Access Article from BMC Nephrology. - March 20, 2019

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Articles from MassDevice - March 19, 2019

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Dialysis Modalities for the Management of Pediatric Acute Kidney Injury - First Online abstract from Pediatric Nephrology. - March 18, 2019

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Study: Research Ties Common Heartburn Medications to Kidney Disease and Failure - Press release from the University at Buffalo. - March 18, 2019

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Diabetes and Chronic Kidney Disease Basics: Part One - Articles in Press Abstract from Journal of Renal Nutrition. - March 17, 2019

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NKF: Partnering on Patient-Centered Research for People with Kidney Disease - Blog posting from the Patient-Centered Outcomes Research Institute. - March 14, 2019

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Mother and Child Reunion in "Hypertensive" End-Stage Renal Disease: Will They Complement Each Other? - Free, Open Access, Online First article from Nephron. - March 14, 2019

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Free, Open Access Article from Canadian Journal of Kidney Health and Disease - March 13, 2019

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Teens with High Blood Pressure at Risk for Kidney Disease in Middle Age - Article from Reuters Health. - March 13, 2019

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Association Between Serum High-Density Lipoprotein Cholesterol Levels and Progression of Chronic Kidney Disease: Results From the KNOW-CKD - Free, Open Access article from the Journal of the American Heart Association. - March 12, 2019

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Newer Antihyperglycemic Drugs Have Distinctive CV, Kidney Benefits - Article from Internal Medicine News. - March 12, 2019

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Computer Kidney Could Provide Safer Tests for New Medications - Press release from the University of Waterloo. - March 11, 2019

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Characteristics and Outcomes of Patients with Cardiogenic Shock Utilizing Hemodialysis for Acute Kidney Injury - Article in Press abstract from the American Journal of Cardiology. - March 9, 2019

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Poor Kidney Function Linked to Higher Cancer Risk - Press release and Published Ahead of Print CJASN abstract from the American Society of Nephrology. - March 8, 2019

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Selection and Receipt of Kidney Replacement in Critically ill Older Patients with AKI - Published Ahead of Print CJASN abstract and editorial extract. - March 7, 2019

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Big Science and Big Data in Nephrology - Free, Full-Text, Articles in Press from Kidney International. - March 4, 2019

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Recasting Kidney Failure as Cardiovascular Disease - Recent findings from AdvancingDialysis.org (sponsored content). - January 2, 2019

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Women And Kidney Disease - Article from Johns Hopkins Medicine. - February 1, 2018

 
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  WEB RESOURCES

blue ball Latest Scientific Journal Articles on Chronic Kidney Disease
Kidney Beginnings: A Patient’s Guide to Living with Reduced Kidney Function - from the American Association of Kidney Patients (AAKP) web site
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Acute Kidney Injury (AKI) Patients - (1-page pdf) Medicare coverage summary and resources from Northwest Renal Network

About Chronic Kidney Disease (CKD) from The National Kidney Foundation web site
American Diabetes Association web site
Are You At Risk for Kidney Disease? from the American Kidney Fund web site
Barriers to successful care for chronic kidney disease (pdf) from BMC Nephrology - October 27, 2005

CDC's Chronic Kidney Disease Initiative - The CKD Initiative currently includes surveillance, epidemiology, and state-based demonstration projects and economic studies in collaboration with partners from other government agencies, universities, and national organizations.

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blue ball Chronic Kidney Disease Change Package from The National Kidney Foundation web site
Chronic Kidney Disease (CKD) Surveillance System - from the Centers for Disease Control (CDC)
Chronic Kidney Disease from the American Association of Kidney Patients (AAKP) web site
Chronic Kidney Disease from the Hypertension, Dialysis, & Clinical Nephrology (HDCN) web site
blue ball Chronic Kidney Disease from the American Kidney Fund web site
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Chronic Kidney Disease patient page from the Journal of the American Medical Association. - May 24/31, 2016

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Clinical Pharmacokinetics in Kidney Disease — Fundamental Principles - Free, Full-Text, CJASN Express Articles - June 2018

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Free eBook To Know about the Correct Way to Prevent and Treat Kidney Failure a 'Common Man's Guide' for World Kidney Day. - March 2019

blue ball Diabetic Kidney Disease - this is a growing library of key high-impact articles in nephrology, chosen by UKidney's contributors as suggested reading for nephrology trainees and practitioners.
Education and Teaching Resources from the Royal Infirmary of Edinburgh Renal Unit web site
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ERA-EDTA Registry Annual Report (covers 2015 data) - (150-page pdf) The ERA-EDTA Registry collects data on renal replacement therapy (RRT) via the national and regional renal registries in Europe and countries bordering the Mediterranean Sea. For this 2015 Annual Report data sets from 52 national or regional renal registries in 36 countries were used.

2008 ESRD Briefing Book for State and Federal Policy Makers (pdf format requires Adobe Acrobat Reader) - from the ANNA web site
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Essentials of Chronic Kidney Disease - KidneyTalk podcast from Renal Support Network

blue ball Frequently Asked Questions About GFR Estimates (pdf) - from the National Kidney Foundation (NKF) web site
blue ball General Nephrology - this is a growing library of key high-impact articles in nephrology, chosen by UKidney's contributors as suggested reading for nephrology trainees and practitioners.
blue ball Guide to Dialysis and Kidney Disease - from the National Council for Aging Care
How to Have a Good Future with Kidney Disease a Life Options CKD Patient Education Toolkit - 2011
blue ball Infographic: Polycystic kidney disease (PKD) from the Mayo Clinic News Network
IgA nephropathy from the About web site
KEY - Kidney Education and You - free kidney education classes from the DaVita web site
Kidney Diseases from the National Institute of Health web site
Kidney Diseases Dictionary from the National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) web site
Kidney Early Evaluation Program (KEEP) from the National Kidney Foundation (NKF) web site
Kidney Health Library from the Kidney & Urology Foundation of America (KUFA) web site
Life Options Rehabilitation Program Introduction to Chronic Kidney Disease
Living Well with Chronic Kidney Disease (pdf) from the American Kidney Fund (AKF) web site
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Mayo Clinic Minute: Understanding Chronic Kidney Disease - 1-minute video.

newMayo Clinic Minute: When Your Kidneys Fail - video and article from the Mayo Clinic web site

blue ball Mayo Clinic Q and A: Understanding chronic kidney disease from the Mayo Clinic web site
Medicare Coverage of Kidney Dialysis & Kidney Transplant Services (pdf) from the Medicare web site
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National Institute of Diabetes and Digestive Diseases (NIDDK) Publications in English and Spanish - July 2014

  • Chronic Kidney Disease and Medicines (Brochure) (EnglishSpanish)
  • Is My Child At Risk for Kidney Disease? (EnglishSpanish)
  • What I need to know about Kidney Failure and How It's Treated (EnglishSpanish)
National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) web site
National Kidney Disease Education Program (NKDEP) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) web site
Northwest Renal Network's Choosing a Treatment Type - 2-page pdf from the NW Renal Network - December 2012
Polycystic Kidney Disease (PKD) Educational Materials from the PKD Foundation web site
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Renal Disorders in Pregnancy: Core Curriculum 2019 - Free, full-text, Article in Press from American Journal of Kidney Diseases. - August 16, 2018

10 Steps for Protecting Kidney Health from the National Kidney Foundation (NKF) web site
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UK's "Think Kidneys" Campaign - 2018

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Understanding Kidney Disease (Four free book chapters) - resource from ISN Education- January 2016

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Updated UK Guideline: Chronic Kidney Disease – Early Identification and Management of Chronic Kidney Disease in Adults in Primary and Secondary Care - July 2014

Uremic Toxins: What Are They? An Integrated Overview of Pathobiology and Classification from the Journal of Renal Nutrition

Video on Failing Kidneys and Different Treatment Options - Posting from the Precious Bodily Fluids blog. - April 2015

What Is Your Kidney Score? from the National Kidney Foundation (NKF) web site
What You Can Do from the Life Options web site
When Your Child Has a Chronic Kidney Disease from the Nemours Foundation web site
 
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  ESSENTIALS AND CLASSICS

Chronic Kidney Disease: What Every Nurse Should Know - from the American Nephrology Nurses Association web site
  • Introduction to Chronic Kidney Disease: An Overview of Causes, Stages, and Treatment
  • Chronic Kidney Disease - Stages 1 through 3
  • Chronic Kidney Disease - Stages 4 and 5: Overview of Therapy Options
  • Kidney Replacement Therapy - Transplantation
  • Kidney Replacement Therapy - Self-Care Dialysis
  • Kidney Replacement Therapy - Assisted Dialysis
  • Chronic Kidney Disease in the Pediatric Population
Core Curriculum: Chronic Kidney Disease - full-text article from the American Journal of Kidney Diseases - January 2007
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Updated Guideline: VA/DoD Clinical Practice Guideline for the Management of Chronic Kidney Disease in Primary Care - Full-text from the National Guideline Clearinghouse. - December 2014

Indicators for Chronic Disease Surveillance (pdf) - article from Morbidity and Mortality Weekly Report (MMWR) - September 10, 2004
Screening, Monitoring, and Treatment of Early Stage Chronic Kidney Disease - recommendations from the American College of Physicians (October 2013)
Risk Factors for CKD from the Life Options web site
10 Symptoms of Kidney Disease from the Life Options web site
Frequently Asked Questions about CKD from the Life Options web site
Learn the Six Warning Signs of Kidney and Urinary Tract Disease from the National Kidney Foundation (NKF) web site
 
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  BEST CLINICAL PRACTICES

The National Kidney Foundation's Kidney Early Evaluation Program (KEEP) is designed to identify those at risk for kidney disease - from the National Kidney Foundation (NKF)
Guidelines for Managing Kidney Disease from the Canadian Medical Association
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Evidence-based Clinical Practice Guidelines from Clinical and Experimental Nephrology - April 2016

Clinical Practice Recommendations for the Care of Infants with Stage 5 Chronic Kidney Disease (CKD5) - Free, full-text review article from Pediatric Nephrology. - September 2013

Testing for Chronic Kidney Disease: A Position Statement From the National Kidney Foundation - full-text article from the American Journal of Kidney Diseases - August 2007

Clinical Practice Recommendations for the Care of Infants with Stage 5 Chronic Kidney Disease - Free, full-text, Online First article from Pediatric Nephrology. - October 2012

Healthy People 2020 - National Institute of Health (NIH) guidelines for managing Chronic Kidney Disease
Elevated levels of serum creatinine: recommendations for management and referral - from the Canadian Medical Association - 1999
 
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  K/DOQI™ -  Kidney Disease Outcomes Quality Initiative

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K/ DOQI Main Page on the National Kidney Foundation web site

 


  KDIGO™ -  Kidney Disease Improving Global Outcomes ( pronounced "kay de go" )

Kidney Disease Improving Global Outcomes (KDIGO) web site

  PUBMED SEARCHES (National Library of Medicine's MEDLINE Database)

Kidney Diseases (General) from MEDLINEplus Health Information
chronic kidney disease Continually Updated!
chronic kidney disease AND risk factors Continually Updated!
MEDLINE / Pubmed Information from the National Library of Medicine
 

  PRODUCTS

 
 

  STATISTICS

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Eleven New Indicators of CKD Have Been Added to the Resources on the CDC's CKD Surveillance System Website - April 2018

View all indicators.

The Chronic Kidney Disease (CKD) Surveillance System - from the Centers for Disease Control (CDC)

Fast Facts on Kidney Disease - Statistics from the National Kidney Foundation

Average Annual Health Care Use and Expenditures for Kidney Disease among Adults 18 and Older, U.S. Civilian Noninstitutionalized Population, 2003-2007 - Statistical brief (7-page pdf) from the Agency for Healthcare Research and Quality
Renal Data Extraction and Referencing (RenDER) System - new online data querying application accessible through the United States Renal Data System (USRDS) - USRDS Presentations & Posters, 2016 Researcher's Guide and the 2018 USRDS annual report - from the United States Renal Data System (USRDS) web site

2014 National Chronic Kidney Disease Fact Sheet - 3-page pdf. - from the Centers for Disease Control (CDC)

US Government Goals: Chronic Kidney Disease Chapter from the Healthy People 2020 Objectives
statehealthfacts.org - your source for state health data
 
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  UPCOMING EVENTS

NKF Health Screening Schedule - The National Kidney Foundation's (NKF) Kidney Early Evaluation Program (KEEP) is designed to identify those at risk for kidney disease - scroll down to view multiple screening dates and contact phone numbers.
The American Association of Kidney Patients (AAKP) Programs & Events
 
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  RELATED TOPICS

Dialysis Outcomes and Topics from the RenalWEB web site Continually Updated!
 
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  INPUT / SUGGESTIONS

E-mail to RenalWEB on the Chronic Kidney Disease Page
 
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