RenalWEB Home Page
Last Updated 07/15/18

Chronic kidney disease (CKD) is permanent kidney damage due to injury or disease. More than 20 million Americans-one in nine adults-have chronic kidney disease, and most don't even know it. More than 20 million others are at increased risk.

How long you can live with CKD depends on your age, other health problems, and how involved you become in your care. Some people with early CKD never experience kidney failure. Others reach kidney failure (end-stage renal disease (ESRD)) and live for decades with dialysis or kidney transplants.

Simple tests in a doctor's office can detect chronic kidney disease in its early stages when lifestyle changes and medication can be prescribed to delay or prevent the progression of kidney disease and its complications. Left untreated, chronic kidney disease may ultimately lead to kidney failure and/or heart disease.

There are many risk factors that make having CKD more likely, with the leading risk factors being diabetes, hypertension, and a family history of CKD.

Warning: Changes should never be made in a patient's treatment or care based solely on the information found here.  All patients have unique healthcare concerns and considerations and these must all be taken into account before any changes can be safely made.  All medical and therapeutic decisions must come from a qualified health care provider.  Read RenalWEB's Legal Disclaimer before proceeding.

  NEWS and LATEST ARTICLES

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Burden of Proof for Tolvaptan in ADPKD — Did REPRISE Provide the Answer? - Free, Full-Text Article from the Clinical Journal of the American Society Of Nephrology. - July 2018

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Postings from the Nephron Power Blog - July 2018

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Adherence to Low-Sodium Dietary Approaches to Stop Hypertension-Style Diet May Decrease the Risk of Incident Chronic Kidney Disease among High-Risk Patients: a Secondary Prevention in Prospective Cohort Study - Free, Full-Text Article from NDT. - July 2018

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Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function — A Community-Based Cohort Study - Abstract and editorial extract from JAMA Internal Medicine. - July 2018

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Management of Acute Kidney Injury: Core Curriculum 2018 - Free, Full-Text Article from American Journal of Kidney Diseases. - July 2018

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Free, Full-Text Articles from Journal of Renal Nutrition - July 2018

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CKD Free, Full-Text Articles from Kidney International - July 2018

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Ventilator-Induced Kidney Injury: Are Novel Biomarkers the Key to Prevention? - Free, full-text, Online First article from Nephron. - July 11, 2018

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Kidney Podocytes, All Grown Up - July 11, 2018

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Renal Replacement Therapy Intensity for Acute Kidney Injury and Recovery to Dialysis Independence - Article via Medscape Nephrology (registration required, but free). - July 11, 2018

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The Physiology of Uric Acid and the Impact of End-Stage Kidney Disease and Dialysis - Early View abstract from Seminars in Dialysis. - July 10, 2018

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Researchers Prevent, Reverse Renal Injury by Inhibiting Immune Regulating Molecule - Press release from Beth Israel Deaconess Medical Center. - July 10, 2018

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Patients with Early Kidney Cancer Benefit from Robotic Partial Nephrectomy - Press release from the University of Southern California. - July 10, 2018

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BD Acquires TVA Medical to Advance Leadership in Solutions for Chronic Kidney Disease - Press release. - July 9, 2018

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Acute Kidney Injury Following Coronary Revascularization Procedures in Patients with Advanced CKD - Advance Article abstract from NDT. - July 9, 2018

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Direct Oral Anticoagulants Linked with Higher Bleeding Risk in Patients with Chronic Kidney Disease - Press release and CJASN Express abstract from the American Society of Nephrology. Article from MedPage Today (registration required). - July 6, 2018

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Regional Variation in Chronic Kidney Disease and Associated Factors in Hypertensive Individuals in Rural South Asia: Findings from Control of Blood Pressure and Risk Attenuation — Bangladesh, Pakistan and Sri Lanka - Free, full-text, Advance Article from NDT. - July 5, 2018

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Dyskalemia in Chronic Kidney Disease: How Concerned Should We Be? - Free, full-text Online First article from Nephron. - July 4, 2018

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Articles in Press Abstracts from American Journal Of Kidney Diseases - July 3, 2018

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Yemeni Ministry of Health: 1,200 Dialysis Patients Died, 9,500 Dying - Article from AhluBayt News Agency (Iran). - July 2, 2018

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Researchers Develop Gene Therapy Method to Target Kidney Cells - Press release and JASN Express abstract from the American Society of Nephrology. - June 29, 2018

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Akebia Therapeutics and Keryx Biopharmaceuticals to Merge, Creating a Fully Integrated ($1B) Company Focused on the Development and Commercialization of Therapeutics for Patients with Kidney Disease - Press release. Article from BioPharma DIVE. - June 28, 2018

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Advance Articles Abstracts from NDT - June 28, 2018

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Potential Policy Approaches to Address Diet-Related Diseases - Free, full-text, New Online viewpoint article from the Journal of the American Medical Association. - June 28, 2018

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Clinical Pharmacokinetics in Kidney Disease — Fundamental Principles - Free, Full-Text, CJASN Express Article. - June 27, 2018

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MedPAC Report on Earlier Initiation of Dialysis as Possible Low-Value Care in Medicare Population - See Chapter 10 (74-page pdf) of the June 2018 report. - June 27, 2018

"We estimate that dialysis spending in 2016 for FFS Medicare beneficiaries who initiated treatment with high levels of kidney function range from $500 million to $1.4 billion."

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The Hidden Epidemic: Worldwide, Over 850 Million People Suffer From Kidney Diseases - Press release from the American Society of Nephrology. - June 27, 2018

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Free, Full-Text, Online First Articles from Nephron - May 23 - June 26, 2018

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Percutaneous Ablation Versus Partial and Radical Nephrectomy for T1a Renal Cancer: A Population-Based Analysis - Latest Article abstract from Annals of Internal Medicine. - June 26, 2018

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The KDIGO Acute Kidney Injury Guidelines for Cardiac Surgery Patients in Critical Care: a Validation Study - Free, Open Access article from BMC Nephrology. - June 25, 2018

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Changes to Chronic Kidney Care Medicare Coverage in Passed House Legislation - Article from Kidney News Online. - June 22, 2018

"A last-minute addition to the legislative package in the House would extend by three months the period people with chronic kidney failure must wait before they become eligible for Medicare coverage."

Editor's note: Politicians must feed their benefactors. Junk-bond nephrology continues to drive U.S. dialysis care public policy.

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Dialysis Use and Mortality in Medicare Versus Veterans Affairs - (Registration required, but free.) Viewpoint article from Medscape Nephrology. - June 22, 2018

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Dulaglutide Preserves Renal Function in Diabetic Kidney Disease - Article from Medscape Nephrology (registration required, but free. - June 22, 2018

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Free, Open Access Articles from BMC Nephrology - June 22, 2018

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Inhaled Nitric Oxide May Reduce Kidney Complications from Heart Surgery - Press release from the American Thoracic Society. - June 22, 2018

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Canagliflozin and Renal Outcomes in Type 2 Diabetes: Results from the CANVAS Program Randomized Clinical Trials - Abstract from The Lancet Diabetes & Endocrinology. - June 21, 2018

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Mortality in Patients with Chronic Renal Disease without Health Insurance in Mexico: Opportunities for a National Renal Health Policy - Article in Press abstract and full-text article (41-page PDF) from Kidney International Reports. - June 20, 2018

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Preparing to Fail: A Useful Tool for Predicting Time to ESRD in Pediatric CKD - Posting from the AJKD blog. - June 19, 2018

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Representation of Patients With Chronic Kidney Disease in Trials of Cancer Therapy - Research letter abstract from the Journal of the American Medical Association. - June 19, 2018

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Bad Habits That Lead to Cancer, Chronic Disease Corrected by Simple Lifestyle Intervention - Press release from Northwestern University. - June 19, 2018

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Childhood Kidney Disease: A Troubling Prognosis? - Free, Full-Text, Article in Press from American Journal Of Kidney Diseases. - June 16, 2018

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Reduction in Protein in the Urine Is a Treatment Goal in Children with Kidney Disease - Press release from the American Society of Nephrology. - June 15, 2018

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Decline in Kidney Function among Apparently Healthy Young Adults at Risk of Mesoamerican Nephropathy - JASN Express abstract. - June 15, 2018

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Recent Clinical Trial Finds Tamsulosin Not Effective in Kidney Stone Passage - June 14, 2018

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Preserving Kidney Health during Intensive Blood Pressure Control - Abstract from Nature Reviews Nephrology. - June 13, 2018

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Food Based Dietary Patterns and Chronic Disease Prevention - Free, full-text article from The BMJ. - June 13, 2018

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Free, Open Access Articles from PLOS One - May 1-June 12, 2018

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Heroin Use Is Associated with AA-Type Kidney Amyloidosis in the Pacific Northwest - CJASN Express abstract. - June 7, 2018

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A Consensus Statement on Health-Care Transition of Patients with Childhood Onset Chronic Kidney Diseases: Providing Adequate Medical Care in Adolescence and Young Adulthood - Free, Open Access article from Clinical and Experimental Nephrology. - June 4, 2018

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A Narrative Review of the Impact of Interventions in Acute Kidney Injury - Free, Open Access article from Journal of Nephrology. - November 29, 2017

 
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  WEB RESOURCES

blue ball Latest Scientific Journal Articles on Chronic Kidney Disease
Kidney Beginnings: A Patient’s Guide to Living with Reduced Kidney Function - from the American Association of Kidney Patients (AAKP) web site
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Acute Kidney Injury (AKI) Patients - (1-page pdf) Medicare coverage summary and resources from Northwest Renal Network

About Chronic Kidney Disease (CKD) from The National Kidney Foundation web site
American Diabetes Association web site
Are You At Risk for Kidney Disease? from the American Kidney Fund web site
Barriers to successful care for chronic kidney disease (pdf) from BMC Nephrology - October 27, 2005

CDC's Chronic Kidney Disease Initiative - The CKD Initiative currently includes surveillance, epidemiology, and state-based demonstration projects and economic studies in collaboration with partners from other government agencies, universities, and national organizations.

blue ball CKD Booklet for Professional - 7.0 edition 2015
Chronic Kidney Disease (CKD) Surveillance System - from the Centers for Disease Control (CDC)
Chronic Kidney Disease from the American Association of Kidney Patients (AAKP) web site
Chronic Kidney Disease from the Hypertension, Dialysis, & Clinical Nephrology (HDCN) web site
blue ball Chronic Kidney Disease from the American Kidney Fund web site
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Chronic Kidney Disease patient page from the Journal of the American Medical Association. - May 24/31, 2016

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new Clinical Pharmacokinetics in Kidney Disease — Fundamental Principles - Free, Full-Text, CJASN Express Articles - June 2018

blue ball Consensus Expert Recommendations for the Diagnosis and Management of Autosomal Recessive Polycystic Kidney Disease: Report of an International Conference (pdf) from the Journal of Pediatrics
blue ball Diabetic Kidney Disease - this is a growing library of key high-impact articles in nephrology, chosen by UKidney's contributors as suggested reading for nephrology trainees and practitioners.
Education and Teaching Resources from the Royal Infirmary of Edinburgh Renal Unit web site
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ERA-EDTA Registry Annual Report (covers 2015 data) - (150-page pdf) The ERA-EDTA Registry collects data on renal replacement therapy (RRT) via the national and regional renal registries in Europe and countries bordering the Mediterranean Sea. For this 2015 Annual Report data sets from 52 national or regional renal registries in 36 countries were used.

2008 ESRD Briefing Book for State and Federal Policy Makers (pdf format requires Adobe Acrobat Reader) - from the ANNA web site
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Essentials of Chronic Kidney Disease - KidneyTalk podcast from Renal Support Network

blue ball Frequently Asked Questions About GFR Estimates (pdf) - from the National Kidney Foundation (NKF) web site
blue ball General Nephrology - this is a growing library of key high-impact articles in nephrology, chosen by UKidney's contributors as suggested reading for nephrology trainees and practitioners.
How to Have a Good Future with Kidney Disease a Life Options CKD Patient Education Toolkit - 2011
blue ball Infographic: Polycystic kidney disease (PKD) from the Mayo Clinic News Network
IgA nephropathy from the About web site
KEY - Kidney Education and You - free kidney education classes from the DaVita web site
Kidney Diseases from the National Institute of Health web site
Kidney Diseases Dictionary from the National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) web site
Kidney Early Evaluation Program (KEEP) from the National Kidney Foundation (NKF) web site
Kidney Health Library from the Kidney & Urology Foundation of America (KUFA) web site
Life Options Rehabilitation Program Introduction to Chronic Kidney Disease
Living Well with Chronic Kidney Disease (pdf) from the American Kidney Fund (AKF) web site
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Mayo Clinic Minute: Understanding Chronic Kidney Disease - 1-minute video.

blue ball Mayo Clinic Q and A: Understanding chronic kidney disease from the Mayo Clinic web site
Medicare Coverage of Kidney Dialysis & Kidney Transplant Services (pdf) from the Medicare web site
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National Institute of Diabetes and Digestive Diseases (NIDDK) Publications in English and Spanish - July 2014

  • Chronic Kidney Disease and Medicines (Brochure) (EnglishSpanish)
  • Is My Child At Risk for Kidney Disease? (EnglishSpanish)
  • What I need to know about Kidney Failure and How It's Treated (EnglishSpanish)
National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) web site
National Kidney Disease Education Program (NKDEP) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) web site
Northwest Renal Network's Choosing a Treatment Type - 2-page pdf from the NW Renal Network - December 2012
Polycystic Kidney Disease (PKD) Educational Materials from the PKD Foundation web site
10 Steps for Protecting Kidney Health from the National Kidney Foundation (NKF) web site
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Understanding Kidney Disease (Four free book chapters) - resource from ISN Education- January 2016

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Updated UK Guideline: Chronic Kidney Disease – Early Identification and Management of Chronic Kidney Disease in Adults in Primary and Secondary Care - July 2014

Uremic Toxins: What Are They? An Integrated Overview of Pathobiology and Classification from the Journal of Renal Nutrition

Video on Failing Kidneys and Different Treatment Options - Posting from the Precious Bodily Fluids blog. - April 2015

What Is Your Kidney Score? from the National Kidney Foundation (NKF) web site
What You Can Do from the Life Options web site
When Your Child Has a Chronic Kidney Disease from the Nemours Foundation web site
 
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  ESSENTIALS AND CLASSICS

Chronic Kidney Disease: What Every Nurse Should Know - from the American Nephrology Nurses Association web site
  • Introduction to Chronic Kidney Disease: An Overview of Causes, Stages, and Treatment
  • Chronic Kidney Disease - Stages 1 through 3
  • Chronic Kidney Disease - Stages 4 and 5: Overview of Therapy Options
  • Kidney Replacement Therapy - Transplantation
  • Kidney Replacement Therapy - Self-Care Dialysis
  • Kidney Replacement Therapy - Assisted Dialysis
  • Chronic Kidney Disease in the Pediatric Population
Core Curriculum: Chronic Kidney Disease - full-text article from the American Journal of Kidney Diseases - January 2007
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Updated Guideline: VA/DoD Clinical Practice Guideline for the Management of Chronic Kidney Disease in Primary Care - Full-text from the National Guideline Clearinghouse. - December 2014

Indicators for Chronic Disease Surveillance (pdf) - article from Morbidity and Mortality Weekly Report (MMWR) - September 10, 2004
Screening, Monitoring, and Treatment of Early Stage Chronic Kidney Disease - recommendations from the American College of Physicians (October 2013)
Risk Factors for CKD from the Life Options web site
10 Symptoms of Kidney Disease from the Life Options web site
Frequently Asked Questions about CKD from the Life Options web site
Learn the Six Warning Signs of Kidney and Urinary Tract Disease from the National Kidney Foundation (NKF) web site
 
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  BEST CLINICAL PRACTICES

The National Kidney Foundation's Kidney Early Evaluation Program (KEEP) is designed to identify those at risk for kidney disease - from the National Kidney Foundation (NKF)
Guidelines for Managing Kidney Disease from the Canadian Medical Association
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Evidence-based Clinical Practice Guidelines from Clinical and Experimental Nephrology - April 2016

Clinical Practice Recommendations for the Care of Infants with Stage 5 Chronic Kidney Disease (CKD5) - Free, full-text review article from Pediatric Nephrology. - September 2013

Testing for Chronic Kidney Disease: A Position Statement From the National Kidney Foundation - full-text article from the American Journal of Kidney Diseases - August 2007

Clinical Practice Recommendations for the Care of Infants with Stage 5 Chronic Kidney Disease - Free, full-text, Online First article from Pediatric Nephrology. - October 2012

Healthy People 2020 - National Institute of Health (NIH) guidelines for managing Chronic Kidney Disease
Elevated levels of serum creatinine: recommendations for management and referral - from the Canadian Medical Association - 1999
 
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  K/DOQI™ -  Kidney Disease Outcomes Quality Initiative

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K/ DOQI Main Page on the National Kidney Foundation web site

 


  KDIGO™ -  Kidney Disease Improving Global Outcomes ( pronounced "kay de go" )

Kidney Disease Improving Global Outcomes (KDIGO) web site

  PUBMED SEARCHES (National Library of Medicine's MEDLINE Database)

Kidney Diseases (General) from MEDLINEplus Health Information
chronic kidney disease Continually Updated!
chronic kidney disease AND risk factors Continually Updated!
MEDLINE / Pubmed Information from the National Library of Medicine
 

  PRODUCTS

 
 

  STATISTICS

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Eleven New Indicators of CKD Have Been Added to the Resources on the CDC's CKD Surveillance System Website - April 2018

View all indicators.

The Chronic Kidney Disease (CKD) Surveillance System - from the Centers for Disease Control (CDC)

Fast Facts on Kidney Disease - Statistics from the National Kidney Foundation

Average Annual Health Care Use and Expenditures for Kidney Disease among Adults 18 and Older, U.S. Civilian Noninstitutionalized Population, 2003-2007 - Statistical brief (7-page pdf) from the Agency for Healthcare Research and Quality
Renal Data Extraction and Referencing (RenDER) System - new online data querying application accessible through the United States Renal Data System (USRDS) - USRDS Presentations & Posters, 2016 Researcher's Guide and the 2017 USRDS annual report - from the United States Renal Data System (USRDS) web site

2014 National Chronic Kidney Disease Fact Sheet - 3-page pdf. - from the Centers for Disease Control (CDC)

US Government Goals: Chronic Kidney Disease Chapter from the Healthy People 2020 Objectives
statehealthfacts.org - your source for state health data
 
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  UPCOMING EVENTS

NKF Health Screening Schedule - The National Kidney Foundation's (NKF) Kidney Early Evaluation Program (KEEP) is designed to identify those at risk for kidney disease - scroll down to view multiple screening dates and contact phone numbers.
The American Association of Kidney Patients (AAKP) Programs & Events
 
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  RELATED TOPICS

Dialysis Outcomes and Topics from the RenalWEB web site Continually Updated!
 
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  INPUT / SUGGESTIONS

E-mail to RenalWEB on the Chronic Kidney Disease Page
 
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